Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Thiamin (as Thiamine Mononitrate)
25 mg
2,083%
Riboflavin
25 mg
1,923%
Niacin (as Nicotinic Acid)
25 mg NE§
156%
Vitamin B6 (as Pyridoxine HCl [25 mg] and Pyridoxal 5-Phosphate [10 mg])
35 mg
2,059%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFEâĄ
170%
Vitamin B12 (as Methylcobalamin)
100 mcg
4,167%
Biotin (as d-Biotin)
300 mcg
1,000%
Pantothenic Acid (as Calcium D-Pantothenate)
100 mg
2,000%
Choline (as Choline Bitartrate)
50 mg
9%
Pantethine
25 mg
â
Inositol
50 mg
â
Top Medical Research Studies
8
We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
8
We investigated how folic acid (FA) affects blood clotting in response to carbon black exposure. Adult mice were exposed to filtered air or carbon black for 28 days. We found that carbon black increased blood clotting and spurred the development of a certain type of blood cells in the spleen. Interestingly, while carbon black lowered folic acid levels, administering FA helped restore normal coagulation by inhibiting certain enzymes in spleen macrophages. This suggests that folic acid could be beneficial in protecting against increased clotting risks related to carbon black exposure.
8
In this case, we observed a 19-year-old man who developed severe peripheral neuropathy and central pulmonary embolism after using nitrous oxide recreationally. Elevated levels of homocysteine and methylmalonic acid indicated vitamin Bââ inactivation due to the substance. After discontinuing nitrous oxide and undergoing treatment with B vitamins for six months, the patient showed remarkable recovery, with symptoms significantly reduced. This highlights that even low levels of nitrous oxide use can lead to serious health issues, including increased blood clot risks. Awareness is crucial for young individuals who may use this substance.
Most Useful Reviews
9
Essential for pregnancy
8 people found this helpful
Many letters on vitamins being vital! This medication is excellent for those with folate cycle mutations. I wish I had discovered this sooner, especially after my loss at eight months of pregnancy due to gene mutations affecting vitamin B9 and B12 assimilation, leading to blood clot issues. Since starting these vitamins alongside my multivitamins, my homocysteine level reduced significantly. Now, I can plan a pregnancy, having seen a drop from 13 to 5.5 within a month. I have experienced no side effects but advise taking the vitamins after a meal to avoid any reactions. This complex is crucial for individuals aware of MTHFR and related issues.
7.5
Great for heart health
These vitamins are excellent! The composition of B vitamins was recommended by my cardiologist, and I love that it includes choline, which helps with protein assimilation, lowers cholesterol, and supports blood vessels and heart health. I consume them in courses and have been very satisfied with the results!
7.5
Lowered homocysteine
19 people found this helpful
I experienced a great reduction in homocysteine, which fell from 9.2 to 5.5 over 50 days while following a low-methionine diet. Itâs hard to say if the vitamins solely contributed, as I also took a multivitamin previously without any results. I highly recommend trying these, especially at a great price! However, I advise caution and suggest taking them for a month or two, followed by maintenance dosing. My vitamin B12 levels have lowered, indicating the vitamins did have a significant impact.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
- All Researches
8
We examined the impact of vitamin B12 deficiency on cerebral venous sinus thrombosis (CVST) through a case series involving three patients. Each case presented symptoms like headaches and, in some instances, visual disturbances. All patients showed elevated homocysteine levels and had low vitamin B12. Treatment included anticoagulation therapy and vitamin supplementation, leading to positive responses and, in two cases, resolution of thrombosis. This suggests that monitoring vitamin B12 levels, particularly in vegetarian diets, is crucial and could help prevent CVST.
8
Vitamin B12 aids in thromboembolism recovery
We observed a rare case of cerebral venous thrombosis (CVT) associated with hyperhomocysteinemia and iron-deficiency anemia due to autoimmune gastritis.
The patient, a 47-year-old woman, experienced serious symptoms like impaired consciousness and motor difficulties. After thorough examinations like CT and MRI, she was treated with anticoagulants and given iron and vitamin B12 supplements.
Remarkably, the patient showed significant improvement and was discharged without neurological deficits, highlighting the potential role of vitamin B12 and iron in managing conditions linked to blood clots.
The patient, a 47-year-old woman, experienced serious symptoms like impaired consciousness and motor difficulties. After thorough examinations like CT and MRI, she was treated with anticoagulants and given iron and vitamin B12 supplements.
Remarkably, the patient showed significant improvement and was discharged without neurological deficits, highlighting the potential role of vitamin B12 and iron in managing conditions linked to blood clots.
8
We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
8
We investigated how folic acid (FA) affects blood clotting in response to carbon black exposure. Adult mice were exposed to filtered air or carbon black for 28 days. We found that carbon black increased blood clotting and spurred the development of a certain type of blood cells in the spleen. Interestingly, while carbon black lowered folic acid levels, administering FA helped restore normal coagulation by inhibiting certain enzymes in spleen macrophages. This suggests that folic acid could be beneficial in protecting against increased clotting risks related to carbon black exposure.
8
In this case, we observed a 19-year-old man who developed severe peripheral neuropathy and central pulmonary embolism after using nitrous oxide recreationally. Elevated levels of homocysteine and methylmalonic acid indicated vitamin Bââ inactivation due to the substance. After discontinuing nitrous oxide and undergoing treatment with B vitamins for six months, the patient showed remarkable recovery, with symptoms significantly reduced. This highlights that even low levels of nitrous oxide use can lead to serious health issues, including increased blood clot risks. Awareness is crucial for young individuals who may use this substance.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential for pregnancy
8 people found this helpful
Many letters on vitamins being vital! This medication is excellent for those with folate cycle mutations. I wish I had discovered this sooner, especially after my loss at eight months of pregnancy due to gene mutations affecting vitamin B9 and B12 assimilation, leading to blood clot issues. Since starting these vitamins alongside my multivitamins, my homocysteine level reduced significantly. Now, I can plan a pregnancy, having seen a drop from 13 to 5.5 within a month. I have experienced no side effects but advise taking the vitamins after a meal to avoid any reactions. This complex is crucial for individuals aware of MTHFR and related issues.
7.5
Great for heart health
These vitamins are excellent! The composition of B vitamins was recommended by my cardiologist, and I love that it includes choline, which helps with protein assimilation, lowers cholesterol, and supports blood vessels and heart health. I consume them in courses and have been very satisfied with the results!
7.5
Lowered homocysteine
19 people found this helpful
I experienced a great reduction in homocysteine, which fell from 9.2 to 5.5 over 50 days while following a low-methionine diet. Itâs hard to say if the vitamins solely contributed, as I also took a multivitamin previously without any results. I highly recommend trying these, especially at a great price! However, I advise caution and suggest taking them for a month or two, followed by maintenance dosing. My vitamin B12 levels have lowered, indicating the vitamins did have a significant impact.
Frequently Asked Questions
9
Essential for pregnancy
8 people found this helpful
Many letters on vitamins being vital! This medication is excellent for those with folate cycle mutations. I wish I had discovered this sooner, especially after my loss at eight months of pregnancy due to gene mutations affecting vitamin B9 and B12 assimilation, leading to blood clot issues. Since starting these vitamins alongside my multivitamins, my homocysteine level reduced significantly. Now, I can plan a pregnancy, having seen a drop from 13 to 5.5 within a month. I have experienced no side effects but advise taking the vitamins after a meal to avoid any reactions. This complex is crucial for individuals aware of MTHFR and related issues.
7.5
Lowered homocysteine
19 people found this helpful
I experienced a great reduction in homocysteine, which fell from 9.2 to 5.5 over 50 days while following a low-methionine diet. Itâs hard to say if the vitamins solely contributed, as I also took a multivitamin previously without any results. I highly recommend trying these, especially at a great price! However, I advise caution and suggest taking them for a month or two, followed by maintenance dosing. My vitamin B12 levels have lowered, indicating the vitamins did have a significant impact.
7.5
Great for heart health
These vitamins are excellent! The composition of B vitamins was recommended by my cardiologist, and I love that it includes choline, which helps with protein assimilation, lowers cholesterol, and supports blood vessels and heart health. I consume them in courses and have been very satisfied with the results!
8
We examined the impact of vitamin B12 deficiency on cerebral venous sinus thrombosis (CVST) through a case series involving three patients. Each case presented symptoms like headaches and, in some instances, visual disturbances. All patients showed elevated homocysteine levels and had low vitamin B12. Treatment included anticoagulation therapy and vitamin supplementation, leading to positive responses and, in two cases, resolution of thrombosis. This suggests that monitoring vitamin B12 levels, particularly in vegetarian diets, is crucial and could help prevent CVST.
8
Vitamin B12 aids in thromboembolism recovery
We observed a rare case of cerebral venous thrombosis (CVT) associated with hyperhomocysteinemia and iron-deficiency anemia due to autoimmune gastritis.
The patient, a 47-year-old woman, experienced serious symptoms like impaired consciousness and motor difficulties. After thorough examinations like CT and MRI, she was treated with anticoagulants and given iron and vitamin B12 supplements.
Remarkably, the patient showed significant improvement and was discharged without neurological deficits, highlighting the potential role of vitamin B12 and iron in managing conditions linked to blood clots.
The patient, a 47-year-old woman, experienced serious symptoms like impaired consciousness and motor difficulties. After thorough examinations like CT and MRI, she was treated with anticoagulants and given iron and vitamin B12 supplements.
Remarkably, the patient showed significant improvement and was discharged without neurological deficits, highlighting the potential role of vitamin B12 and iron in managing conditions linked to blood clots.
8
We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.
More research is needed to fully understand the potential of folate in preventing thrombosis in this population.
8
We investigated how folic acid (FA) affects blood clotting in response to carbon black exposure. Adult mice were exposed to filtered air or carbon black for 28 days. We found that carbon black increased blood clotting and spurred the development of a certain type of blood cells in the spleen. Interestingly, while carbon black lowered folic acid levels, administering FA helped restore normal coagulation by inhibiting certain enzymes in spleen macrophages. This suggests that folic acid could be beneficial in protecting against increased clotting risks related to carbon black exposure.
References
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. 10.4103/aam.aam_138_23
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. 10.1177/19714009221147224
- Tu YR, Tu KH, Lee CC, Fan PC, Yen CL, et al. Supplementation with Folic Acid and Cardiovascular Outcomes in End-Stage Kidney Disease: A Multi-Institution Cohort Study. Nutrients. 2022;14. 10.3390/nu14194162
- Meng Q, Li B, Huang N, Wei S, Ren Q, et al. Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential. J Hazard Mater. 2022;424:127354. 10.1016/j.jhazmat.2021.127354
- Pedersen OB, Hvas AM, Grove EL. A 19-Year-Old Man with a History of Recreational Inhalation of Nitrous Oxide with Severe Peripheral Neuropathy and Central Pulmonary Embolism. Am J Case Rep. 2021;22:e931936. 10.12659/AJCR.931936
- Al Sulaiman K, Aljuhani O, Al Dossari M, Alshahrani A, Alharbi A, et al. Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study. Crit Care. 2021;25:223. 10.1186/s13054-021-03648-9
